This is the final program frozen on March 29th 2016. For any requested changes of the program after this date please review the bottom of this page under „last minute changes"
Keynote Lectures:
Rui Costa, Portugal
Generating and shaping novel action repertoires
René Hen, USA
Harnessing hippocampal neurogenesis to improve mood and cognition
Robert Malenka, USA
Molecular mechanisms of LTP
Thomas Mrsic-Flogel, Switzerland
The principles of connectivity in the neocortex
Zoltan Nusser, Hungary
Structural, molecular and functional diversity of hippocampal synapses
Special Guest Lecture:
Sebastian Bonhoeffer, Switzerland
Contact networks and infectious disease evolution
Symposia
Special Interest Sessions
Posters
Program schedule
Saturday
April 2 Afternoon
15:00 - 16:00 Registration
16:00 - 17:00 Welcome Cocktail and Poster Session 1
17:00 - 19:00 Symposium 1
Spatial integration of physiological signals by astroglia
Chair: DMITRI RUSAKOV (UK)
Andrea Volterra (Switzerland) 3D Ca2+ imaging provides a new integrative view on astrocyte communications
Christian Henneberger (Germany) Structural plasticity of the tripartite synapse controls glutamate signaling
Natalie Rouach (France) Integration of hippocampal fast oscillations by astrocytes: how and what for?
Dmitri Rusakov (UK) Nanomolar Ca2+ landscapes and spatial signal summation inside astroglia
19:00 - 19:45 Keynote Lecture 1
THOMAS MRSIC-FLOGEL (Switzerland) The principles of connectivity in the neocortex
Sunday
April 3 Morning
08:15 – 09:00 Keynote Lecture 2
RENE HEN (USA) Harnessing hippocampal neurogenesis to improve mood and cognition
09:00 - 11:00 Symposium 2
Making a cortical neuron: progenitors and stem cells
Chair: VICTOR TARABYKIN (Germany)
Wieland Huttner (Germany) Neural Stem and Progenitor Cells and Neocortex Expansion in Development and Evolution
Robert Hevner (USA) Laminar fate and regional identity: transcriptional control in 4 dimensions
Victor Tarabykin (Germany) Non-catalytic TrkC receptor controls cell fate of neocortical progenitors
Alessandra Pierani (France) Transient moving organizers and evolution of the neocortex
11:00 - 11:20 Coffee Break
11:20 - 13:20 Symposium 3
Actin regulators in neuronal development, plasticity and regeneration
Chairs: MICHAEL FROTSCHER AND FRANK BRADKE (Germany)
Michael Frotscher (Germany)
Reelin and cofilin coordinate the migration of cortical neurons
Britta Qualmann (Germany) Novel mechanisms of controlling actin filament formation in neuro-morphogenesis
Walter Witke (Germany) Profilin and the WAVE-complex in neuronal development and synaptic function
Frank Bradke (Germany) Conditioning drives axon regeneration by cofilin mediated actin turnover
13:30 - 15:30 Special Interest Session 1
The role of α-Synuclein in the pathogenesis of Parkinson’s Disease
Chair: MATHIAS BÄHR (Germany)
Jörg Schulz (Germany) Mitochondria and autophagy in α-synuclein toxicity
Donato Di Monte (Germany) Brain propagation of α-synuclein in animal models
Jochen Klucken (Germany) The multivesicular body compartment – linking intracellular degradation and extracellular secretion of aSyn
Mathias Bähr (Germany) New therapeutic approaches in Parkinson’s disease
Sunday
April 3 Afternoon
16:00 – 18:00 Symposium 4
Synaptic defects in epilepsy
Chair: MATTHIJS VERHAGE (The Netherlands)
Susanne Schoch (Germany) Identification of a novel signaling cascade in epileptogenesis
Jakob Sorensen (Denmark) SNAP25/munc18-1 gene dosage, synaptic defects and epilepsy
Ruud Toonen (The Netherlands) STXBP1 mutations in Ohtahara syndrom, synaptic defects and epilepsy
Ira Milosevic (Germany)
Epilepsy as a disease of impaired synaptic vesicle recycling
18:00 - 18:20 Coffee Break
18:20 - 20:20 Symposium 5
Dynamics and function of the Glutamate receptosome: critical modulator of synaptic efficacy
Chair: JULIE PERROY (France)
Julie Perroy (France) Dynamics of the Glutamate Receptosome to control synaptic excitability in physiological and pathological conditions
Camilla Bellone (Switzerland) Shank3 controls maturation of social reward circuits in the VTA
Laurent Groc (France) Dynamics of NMDA receptors: new angle on physiopathological functions
Angela Cenci (Sweden) Signaling interactions between D1 and mGluR5 in the parkinsonian striatum
Monday
April 4 Morning
08:15 - 09:00 Keynote Lecture 3
RUI COSTA (Portugal) Generating and shaping novel action repertoires
09:00 - 11:00 Symposium 6
The neural circuitry of sleep and appetite
Chair: WILLIAM WISDEN (UK)
William Wisden (UK) Capturing the sleep drive using genetic tagging
Antoine Adamantidis (Switzerland) Dissecting peptide and small transmitter co-release: orexin and glutamate evoke nonredundant computations in target neurons
Lora Heisler (UK) Hypoglycemia and energy balance
Denis Burdakov (UK) Neural circuits, instincts, sleep and appetite
11:00 - 11:20 Coffee Break
11:20 - 13:20 Special Interest Session 2
Cell- and biomaterial-based approaches for stroke and spinal cord injury repair
Chair: EVA SYKOVA (Czech Republic)
Srecko Gajovic (Croatia) In vivo imaging of mouse brain repair and stem cell applications after ischemic injury
Ioanna Sandvig (Norway) In situ tissue engineering strategies for stroke repair
Axel Sandvig (Norway) Multimodal neuroimaging and bioengineering applications for visualisation of blood brain barrier crossing and therapeutics in the CNS
Pavla Jendelova (Czech Republic) Stem cells and anti-inflammatory treatment in SCI
Sarka Kubinova (Czech Republic) Natural versus synthetic hydrogels as scaffolds for spinal cord injury repair
13:30 - 15:30 Special Interest Session 3
Modelling disease state networks in human and animal brains for understanding pathophysiolgy, predicting outcomes and improving therapy
Chair: WOLFGANG SOMMER (Germany) and SANTIAGO CANALS (Spain)
Wolf Singer (Germany) Information processing in high dimensional
dynamic space: A novel concept for the interpretation of disease states?
Maria Ercsey-Ravasz (Romania) A predictive network model of cerebral cortical connectivity based on a distance rule
Angelo Bifone (Italy) Brain connectivity in health and disease: a graph theoretical approach
Hamid Noori (Germany) A dynamical model of the neurochemical connectome of the rat brain
Martin Walter, (Germany) Integrating molecular information on excitatory and inhibitory neurotransmission into functional network architectures
Rainer Spanagel, (Germany, Discussant) Can systems approaches provide added value for research and clinical practise in alcoholism
Monday
April 4 Afternoon
16:00 - 18:00 Symposium 7
Imaging plasticity in the mouse visual cortex
Chair: TOBIAS ROSE & MARK HüBENER (Germany)
Sonja Hofer (Switzerland) Neuronal correlates of visual discrimination learning in the visual cortex
Georg Keller (Switzerland) Sensory-motor interactions in mouse visual cortex
Cris Niell (USA) Large scale imaging of cortical activation patterns during learning
Tobias Rose (Germany) Visual cortex neurons recover their initial feature selectivity after monocular deprivation
18:00 - 18:20 Coffee Break
18:20 - 20:20 Symposium 8 - Big Data! So what?
Chair: BENCE öLVECZKY (USA)
Florian Engert (USA) The big data problem: turning maps into knowledge
Bence P. ölveczky (USA) Insights gained from continuous longterm neural recordings in freely behaving animals
Adam Kampff (UK) Fast, Deep, and at a Network Scale: Distributed, whole-brain, single-unit electrical recordings
Tuesday
April 5 Morning
08:15 - 09:00 Keynote Lecture 4
ROBERT MALENKA (USA) Molecular mechanisms of LTP
09:00 - 11:00 Symposium 9
Intrinsic and Extrinsic Control of Neural Stem Cell Behavior and the Neurogenic Environment
Chair: SIMON HIPPENMEYER (Austria)
Simon Hippenmeyer (Austria) Programmed Deterministic Genesis of Neurons and Glia in the Neocortex
Yukiko Gotoh (Japan) Molecular Mechanisms Regulating the Neurogenic Stem Cell Niche in the Embryo and Adult Brain
Caren Norden (Germany) Growth and Differentiation in the Zebrafish Retinal Neuroepithelium
David Solecki (USA) Germinal Zone Oxygen Tension Controls Cerebellar Granule Neuron Progenitor Polarization and Radial Migration through the Zeb1 Transcritption Factor
11:00 - 11:20 Coffee Break
11:20 - 13:20 Special Interest Session 3
Neural Extracellular Matrix: new functions and signaling pathways in neuroplasticity
Chair: ALEXANDER DITYATEV (Germany)
Evgeni Ponimaskin (Germany) Functional interplay between 5-HT7R, MMP-9, and CD44 in the regulation of neuronal plasticity
Sabine Spijker (The Netherlands) Cognitive disturbances due to alterations in CA1 perineuronal nets in a rat model of depression
Alexander Dityatev (Germany) The dual role extracellular matrix in neuroplasticity
Michael Druzin (Sweden) Extracellular matrix setting the mode of GABAergic neurotransmission
Tuesday
April 5 Afternoon
16:00 - 18:00 Symposium 10
Neural Circuits underlying Innate Behaviors
Chair: THOMAS MRSIC-FLOGEL (Switzerland)
Tiago Branco (UK) A neural circuit module for computing escape decisions during foraging
Rich Krauzlis (USA) Subcortical control of attention
Susana Lima (Portugal) Keep Calm and Blame the Hormones: neural mechanisms underlying behavioral modulation by sex hormones
Jan Gründemann (Switzerland) Mapping the neuronal code of fear
18:00 - 19:00 Coffee Break and Poster Session 2
19:00 - 19:45 Special Lecture:
SEBASTIAN BONHOEFFER (Switzerland) Contact networks and infectious disease evolution
20:00 Gala Dinner (free for Das Central residents, 50,- € for residents of other hotels, please book at registration desk)
Wednesday
April 6 Morning
08:15 - 09:00 Keynote Lecture 5
ZOLTAN NUSSER (Hungary) Structural, molecular and functional diversity of hippocampal synapses
09:00 - 11:00 Symposium 11
Adult neurogenesis and memory formation
Chair: PAUL FRANKLAND (Canada) & STEPHAN SCHWARZACHER (Germany)
Paul Frankland (Canada)
Hippocampal neurogenesis and forgetting
Sophie Tronel (France)
Role of adult hippocampal neurogenesis in spatial memory reconsolidation
Stephan Schwarzacher (Germany) Highly dynamic dendritic and synaptic plasticity in new granule cells
Carlos Fitzsimons (Netherlands) Regulation of Adult hippocampal neurogenesis by Glucocorticoids within and outside the stress response. Implications for depression and neurodegenerative diseases
11:00-11:20 Coffee Break
11:20-13:20 Symposium 12
Becoming a cortical neuron: identity and diversity
Chair: ROBERT HEVNER (USA)
Zoltán Molnár (UK) Layer 6b, a cortical layer without known function
Sonia Garel (France) Neuronal and immune orchestration of forebrain wiring
Stefan Britsch (Germany) Bcl11a (Ctip1) controls migration of cortical upper-layer projection neurons through regulation of Sema3c
Gregory Wulczyn (Germany) The miRNA miR-128 is a timer for the functional maturation of cortical progenitors
13:20 End of the Meeting
Last Minute Changes:
1. 2016-03-30 Change of title – Session Monday April 4th Afternoon
Speaker: Sonja Hofer
The new title is: “Making sense of what you see: brain circuits for active vision”
2. 2016-04-02 Change of speaker and title - Session Monday April 4th Afternoon:
The talk by Cris Niell will be replaced by Mark Huebener with a talk entitled:
“Transplanted embryonic neurons integrate into adult neocortical circuits